SCHEMBL599242

SCHEMBL599242

C[C@@H](C(=O)Oc1c(-c2cccc3ccccc23)cccc1-c1cccc2ccccc12)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.50
AKR1C2 P52895 1/20 0.50
PPARG P37231 7/20 0.46
PPARA Q07869 7/20 0.46
L3MBTL1 Q9Y468 1/20 0.43
ALOX5 P09917 1/20 0.43
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
PPARD Q03181 1/20 0.40
GSK3B P49841 1/20 0.40
ADK P55263 1/20 0.40
PTGS1 P23219 1/20 0.40
PTGS2 P35354 1/20 0.40
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
AKR1B1 P15121 1/20 0.39
CTNNB1 P35222 1/20 0.38
KMT2A Q03164 1/20 0.38
GPR84 Q9NQS5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10708475 0.81 ALDH1A1 (0.54) L3MBTL1PTGS1PTGS2KDM4EALDH1A1
SCHEMBL599426 0.80 AKR1C3 (0.50) AKR1C3AKR1C2PPARGPPARAL3MBTL1
SCHEMBL28690577 0.74 AKR1C3 (0.59) AKR1C3AKR1C2PPARGPPARAALOX5
SCHEMBL599730 0.72 ALDH1A1 (0.47) AKR1C3AKR1C2CYP2C9CYP2C19PTGS1
Bicarbonate SCHEMBL11569280 0.72 NR4A1 (0.58) AKR1C3AKR1C2PPARGPPARAALOX5
SCHEMBL8455676 0.72 AKR1C3 (0.64) AKR1C3AKR1C2PPARGPPARACYP2C9
SCHEMBL1046956 0.71 L3MBTL1 (0.61) L3MBTL1PTGS1PTGS2ALDH1A1KMT2A
SCHEMBL10029026 0.71 L3MBTL1 (0.61) L3MBTL1PTGS1PTGS2ALDH1A1KMT2A
SCHEMBL28129662 0.70 ALDH1A1 (0.51) AKR1C3AKR1C2PPARGPPARAALOX5
Bicarbonate SCHEMBL27535643 0.70 NR4A1 (0.56) AKR1C3AKR1C2PPARGPPARAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115008-B2 Method for producing optically active ester and method for producing optically active carboxylic acid TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-02-14 US disclosed