Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546125 | 0.89 | KDM4E (0.51) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL28714647 | 0.83 | KDM4E (0.51) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL29444747 | 0.83 | KDM4E (0.51) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL20272350 | 0.83 | KDM4E (0.51) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL5992714 | 0.82 | KDM4E (0.48) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL1545676 | 0.78 | ALDH1A1 (0.45) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6794906 | 0.77 | MTNR1A (0.49) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9256424 | 0.75 | KDM4E (0.53) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9412075 | 0.75 | KDM4E (0.53) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL16372412 | 0.74 | MTNR1A (0.46) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39198-E1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. (US) | 2006-07-18 | — | — | US | disclosed |
| US-5364866-A | Side effect reduction | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-11-15 | — | — | US | disclosed |