Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038005 | 0.81 | KDM4C (0.50) | ALDH1A1HPGDHTTALOX15HSD17B10 | |
| SCHEMBL27140315 | 0.81 | PDE4D (0.59) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL24906442 | 0.80 | PDE4D (0.53) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL10860621 | 0.80 | KDM4E (0.51) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL31278376 | 0.79 | KDM4E (0.48) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL7715367 | 0.79 | HPGD (0.48) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL28802616 | 0.79 | CYP1A2 (0.49) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL18209960 | 0.79 | PDE4D (0.56) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL30964220 | 0.79 | MAPT (0.49) | ALDH1A1HPGDHTTKDM4ERECQL | |
| SCHEMBL3263632 | 0.77 | CYP1A2 (0.47) | ALDH1A1HPGDHTTKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10220030-B2 | Amino-quinolines as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-05 | — | — | US | disclosed |
| US-10220030-B2 | Amino-quinolines as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-05 | — | — | US | disclosed |
| US-20180085365-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-03-29 | — | — | US | disclosed |
| US-20180085365-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-03-29 | — | — | US | disclosed |
| US-20180085365-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-03-29 | — | — | US | disclosed |
| US-20170128437-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-05-11 | — | — | US | disclosed |
| US-20170128437-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-05-11 | — | — | US | disclosed |
| US-20170128437-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-05-11 | — | — | US | disclosed |
| US-9604963-B2 | Amino-quinolines as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| US-9604963-B2 | Amino-quinolines as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| EP-2603218-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012122011-A2 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012122011-A2 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012021580-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012021580-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | WO | disclosed |
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| WO-1985001732-A1 | 8-SUBSTITUTED PYRAZOLOPENTATHIEPINS AND RELATED COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-25 | — | — | WO | disclosed |
| EP-0138622-A2 | 8-substituted pyrazolopentathiepins and related compounds | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | ABL1, MAP3K20, MAP3K19 | ALDH1A1 3151/4885HPGD 3069/4885HTT 3253/4885 |
| US-10220030-B2 | Amino-quinolines as kinase inhibitors | ABL1, MAP3K3, MAP3K7 | ALDH1A1 3743/4885HPGD 4040/4885HTT 4508/4885 |
| US-20180085365-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K3, MAP3K7 | ALDH1A1 3743/4885HPGD 4040/4885HTT 4508/4885 |
| US-20170128437-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | ABL1, MAP3K3, MAP3K7 | ALDH1A1 3743/4885HPGD 4040/4885HTT 4508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.