SCHEMBL5996318

SCHEMBL5996318

Cc1cc(C)c(C(=O)[PH](=O)CCC(=O)c2c(Cl)cccc2Cl)c(C)c1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
FEN1 P39748 1/20 0.38
RAB9A P51151 3/20 0.36
LMNA P02545 2/20 0.35
ALDH1A1 P00352 1/20 0.34
PTGS2 P35354 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.33
GAA P10253 3/20 0.32
POLB P06746 2/20 0.32
HPGD P15428 1/20 0.32
KDM4E B2RXH2 1/20 0.32
TYK2 P29597 1/20 0.32
TSHR P16473 1/20 0.32
MAPT P10636 2/20 0.32
DOT1L Q8TEK3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5996459 0.90 FEN1 (0.41) KMT2AFEN1ALDH1A1PTGS2TYK2
SCHEMBL5995199 0.88 RAB9A (0.36) KMT2AMEN1FEN1RAB9ALMNA
SCHEMBL5996625 0.88 RAPGEF4 (0.36) KMT2AMEN1RAB9ALMNAALDH1A1
SCHEMBL5997542 0.87 MAPT (0.36) KMT2AMEN1RAB9ALMNAALDH1A1
SCHEMBL5997924 0.87 MAPT (0.36) KMT2AMEN1RAB9ALMNAALDH1A1
SCHEMBL5996163 0.84 KMT2A (0.34) KMT2AMEN1LMNAALDH1A1RAPGEF4
SCHEMBL5996320 0.84 FFAR1 (0.34) KMT2AMEN1FEN1LMNAALDH1A1
SCHEMBL5994378 0.81 SMN1; SMN2 (0.38) KMT2AMEN1LMNAALDH1A1RAPGEF4
SCHEMBL5995748 0.80 MAPT (0.37) ALDH1A1GAAPOLBHPGDKDM4E
SCHEMBL5997089 0.79 CA12 (0.40) KMT2AMEN1ALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 US disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 US disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 KMT2A 1784/4885MEN1 3862/4885FEN1 3857/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 KMT2A 761/4885MEN1 2456/4885FEN1 4789/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 KMT2A 1577/4885MEN1 3695/4885FEN1 4113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.