SCHEMBL5996440

SCHEMBL5996440

Cc1cc(C)c(C(=O)[PH](=O)CCC(=O)c2c(C)cc(C(C)(C)C)cc2C)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ALDH1A1 P00352 3/20 0.34
MAPT P10636 3/20 0.34
MAPK1 P28482 1/20 0.34
HTR1D P28221 1/20 0.33
HTR1B P28222 1/20 0.33
RXRB P28702 4/20 0.33
RXRA P19793 3/20 0.33
GAA P10253 2/20 0.33
RAB9A P51151 3/20 0.33
NPC1 O15118 1/20 0.33
RXRG P48443 1/20 0.32
MEN1 O00255 2/20 0.32
LMNA P02545 2/20 0.32
KMT2A Q03164 2/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 2/20 0.31
TSHR P16473 1/20 0.31
ELANE P08246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5995828 1.00 KDM4E (0.35) KDM4EL3MBTL1ALDH1A1MAPTMAPK1
SCHEMBL5993536 0.96 HTR1D (0.36) ALDH1A1MAPTHTR1DHTR1BRXRB
SCHEMBL5995848 0.89 ACHE (0.35) ALDH1A1MAPTHTR1DHTR1BRXRB
SCHEMBL5997838 0.89 ACHE (0.35) ALDH1A1MAPTHTR1DHTR1BRXRB
SCHEMBL5996052 0.87 CNR2 (0.33) KDM4EALDH1A1MAPTGAALMNA
SCHEMBL5997542 0.84 MAPT (0.36) KDM4EL3MBTL1ALDH1A1MAPTMAPK1
SCHEMBL5997924 0.84 MAPT (0.36) KDM4EL3MBTL1ALDH1A1MAPTMAPK1
SCHEMBL5995871 0.84 ACLY (0.33) HTR1DHTR1BKMT2A
SCHEMBL5995199 0.83 RAB9A (0.36) L3MBTL1ALDH1A1MAPTRXRBRXRA
SCHEMBL5994053 0.83 ACHE (0.33) HTR1DHTR1BRXRBRXRARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 US disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 US disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 KDM4E 3308/4885L3MBTL1 1852/4885ALDH1A1 974/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 KDM4E 662/4885L3MBTL1 1879/4885ALDH1A1 1088/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 KDM4E 2655/4885L3MBTL1 2570/4885ALDH1A1 835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.