Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5150129 | 1.00 | MAPK1 (0.50) | MAPK1TSHRUSP7PDK1VCAM1 | |
| SCHEMBL5996588 | 1.00 | MAPK1 (0.50) | MAPK1TSHRUSP7PDK1VCAM1 | |
| SCHEMBL10019193 | 0.86 | PDK1 (0.58) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL27778996 | 0.83 | PDK1 (0.49) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL5997474 | 0.83 | LMNA (0.55) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL5997466 | 0.83 | LMNA (0.55) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL27688490 | 0.83 | MAPK1 (0.50) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL5997462 | 0.83 | LMNA (0.55) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL10652736 | 0.81 | PDK1 (0.47) | MAPK1TSHRPDK1VCAM1ALDH1A1 | |
| SCHEMBL22730090 | 0.81 | TSHR (0.58) | MAPK1TSHRPDK1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235007-A1 | Substituted 1,4-diazepines and uses thereof | LU TIANBAO | 2006-10-19 | — | — | US | disclosed |
| EP-1712235-A2 | Combinational therapy involving a small molecule inhibitor of the MDM2: P53 interaction | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-7115598-B2 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20050227932-A1 | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2005-10-13 | — | — | US | disclosed |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235007-A1 | Substituted 1,4-diazepines and uses thereof | MDM2, TP53, RB1 | MAPK1 3706/4885TSHR 513/4885USP7 1055/4885 |
| US-20050227932-A1 | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction | TP53, MDM2, TP53BP1 | MAPK1 2293/4885TSHR 3079/4885USP7 2324/4885 |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | TP53, MDM2, HRH2 | MAPK1 3747/4885TSHR 1587/4885USP7 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.