Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.44 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5997466 | 1.00 | LMNA (0.55) | LMNATP53HTTMAPK1TSHR | |
| SCHEMBL5997474 | 1.00 | LMNA (0.55) | LMNATP53HTTMAPK1TSHR | |
| SCHEMBL10019193 | 0.86 | PDK1 (0.58) | LMNAMAPK1TSHRVCAM1PDE7A | |
| SCHEMBL5996588 | 0.83 | MAPK1 (0.50) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL5150129 | 0.83 | MAPK1 (0.50) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL5996591 | 0.83 | MAPK1 (0.50) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL27688490 | 0.83 | MAPK1 (0.50) | LMNAMAPK1TSHRVCAM1PDE7A | |
| SCHEMBL5497079 | 0.81 | TDP1 (0.56) | TP53HTTMAPK1TSHRALDH1A1 | |
| SCHEMBL31657750 | 0.80 | MAPK1 (0.55) | LMNAMAPK1TSHRVCAM1PDE7A | |
| SCHEMBL20072320 | 0.80 | MAPK1 (0.47) | LMNAMAPK1TSHRVCAM1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117126108-A | Preparation method of Ensitrelvir intermediate | 重庆博腾制药科技股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| US-20060235007-A1 | Substituted 1,4-diazepines and uses thereof | LU TIANBAO | 2006-10-19 | — | — | US | disclosed |
| EP-1712235-A2 | Combinational therapy involving a small molecule inhibitor of the MDM2: P53 interaction | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-7115598-B2 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20050227932-A1 | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2005-10-13 | — | — | US | disclosed |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235007-A1 | Substituted 1,4-diazepines and uses thereof | MDM2, TP53, RB1 | LMNA 3920/4885TP53 2/4885HTT 400/4885 |
| US-20050227932-A1 | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction | TP53, MDM2, TP53BP1 | LMNA 3794/4885TP53 1/4885HTT 1312/4885 |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | TP53, MDM2, HRH2 | LMNA 3185/4885TP53 1/4885HTT 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.