Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.53 |
| ▸ | CHRM5 known ✓ | P08912 | 3/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.46 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200645 | 0.98 | ACHE (0.54) | ACHEMAPTBLMADRA2AADRA1A | |
| SCHEMBL3423192 | 0.84 | DGKA (0.55) | TSHRDGKA | |
| Bromide SCHEMBL1161318 | 0.84 | ACHE (0.49) | ACHEMAPTBLMADRA2AADRA1A | |
| SCHEMBL3502248 | 0.83 | TSHR (0.58) | RAD52NPSR1TSHRDGKA | |
| SCHEMBL11142420 | 0.83 | TSHR (0.53) | TSHRDGKA | |
| SCHEMBL16264235 | 0.81 | TSHR (0.67) | RAD52NPSR1TSHRDGKA | |
| SCHEMBL5309960 | 0.81 | TSHR (0.67) | RAD52NPSR1TSHRDGKA | |
| SCHEMBL7522565 | 0.81 | TSHR (0.67) | RAD52NPSR1TSHRDGKA | |
| SCHEMBL20604283 | 0.81 | TSHR (0.67) | RAD52NPSR1TSHRDGKA | |
| SCHEMBL4537822 | 0.81 | TSHR (0.67) | RAD52NPSR1TSHRDGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030176-B2 | Recording medium with nanoparticles and methods of making the same | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| US-20030021983-A1 | Recording medium with nanoparticles and methods of making the same | KIMBERLY-CLARK WORLDWIDE, INC. | 2003-01-30 | — | — | US | disclosed |