SCHEMBL599731

SCHEMBL599731

O=C(O)[C@H](CC(c1cccc2ccccc12)c1cccc2ccccc12)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
SLC6A4 P31645 1/20 0.48
CYP2C19 P33261 3/20 0.46
CYP2C9 P11712 2/20 0.46
HPGD P15428 1/20 0.46
HTT P42858 1/20 0.46
ACP3 P15309 3/20 0.43
CYP1A2 P05177 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
AKR1C3 P42330 1/20 0.39
AKR1C2 P52895 1/20 0.39
CTNNB1 P35222 1/20 0.39
EPHX2 P34913 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL600003 0.90 ACP3 (0.47) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL598816 0.90 ALDH1A1 (0.45) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL606227 0.86 GAA (0.47) ALDH1A1TDP1AKR1C3AKR1C2
SCHEMBL599641 0.86 ALDH1A1 (0.52) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL28326874 0.80 CYP2C9 (0.59) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL1863359 0.78 CYP2C9 (0.49) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL6366676 0.78 CYP2C9 (0.49) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL6366679 0.78 CYP2C9 (0.49) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD
SCHEMBL11542549 0.77 CYP2C9 (0.46) ALDH1A1CYP2C19CYP2C9HPGDHTT
SCHEMBL27347245 0.77 ALDH1A1 (0.57) ALDH1A1SLC6A4CYP2C19CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115008-B2 Method for producing optically active ester and method for producing optically active carboxylic acid TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-02-14 US disclosed