SCHEMBL606227

SCHEMBL606227

COc1ccc([C@@H](CC(c2cccc3ccccc23)c2cccc3ccccc23)C(=O)O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.47
MGAM O43451 2/20 0.47
SI P14410 2/20 0.47
MGAM2 Q2M2H8 2/20 0.47
KMT2A Q03164 5/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
AKR1C3 P42330 3/20 0.45
AKR1C2 P52895 3/20 0.45
AKR1C1 Q04828 1/20 0.45
PTGS1 P23219 1/20 0.45
KDM4E B2RXH2 3/20 0.43
GLA P06280 2/20 0.43
MEN1 O00255 4/20 0.43
ALDH1A1 P00352 4/20 0.43
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
MITF O75030 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL599731 0.86 ALDH1A1 (0.54) TDP1AKR1C3AKR1C2ALDH1A1
SCHEMBL598816 0.85 ALDH1A1 (0.45) GAAMGAMSIMGAM2KMT2A
SCHEMBL600003 0.83 ACP3 (0.47) GAAMGAMSIMGAM2KMT2A
Acetic Acid SCHEMBL28094248 0.77 KMT2A (0.49) GAAMGAMSIMGAM2KMT2A
SCHEMBL13295547 0.75 NR3C1 (0.58) KMT2AL3MBTL1NPC1RAB9ATDP1
SCHEMBL7221229 0.75 KMT2A (0.48) GAAKMT2AL3MBTL1NPC1RAB9A
SCHEMBL8849956 0.74 AKR1C3 (0.55) GAAMGAMSIMGAM2L3MBTL1
SCHEMBL13295548 0.74 NR3C1 (0.50) GAAKMT2AL3MBTL1NPC1RAB9A
SCHEMBL7538949 0.74 AKR1C3 (0.53) GAAKMT2AL3MBTL1RAB9ATDP1
SCHEMBL10827631 0.74 NPC1 (0.51) KMT2AL3MBTL1NPC1RAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115008-B2 Method for producing optically active ester and method for producing optically active carboxylic acid TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-02-14 US disclosed