SCHEMBL600003

SCHEMBL600003

O=C(O)[C@H](CC(c1cccc2ccccc12)c1cccc2ccccc12)c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.47
ALDH1A1 P00352 2/20 0.45
POLB P06746 2/20 0.45
KMT2A Q03164 2/20 0.44
MGAM O43451 2/20 0.43
GAA P10253 2/20 0.43
SI P14410 2/20 0.43
MGAM2 Q2M2H8 2/20 0.43
CYP2C19 P33261 3/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 2/20 0.42
PTGES O14684 1/20 0.42
ALOX5 P09917 1/20 0.42
PPARG P37231 1/20 0.42
HTT P42858 2/20 0.41
HPGD P15428 1/20 0.41
UTS2R Q9UKP6 1/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL599731 0.90 ALDH1A1 (0.54) ACP3ALDH1A1CYP2C19CYP1A2CYP2C9
SCHEMBL598816 0.86 ALDH1A1 (0.45) ACP3ALDH1A1POLBKMT2AMGAM
SCHEMBL606227 0.83 GAA (0.47) ALDH1A1KMT2AMGAMGAASI
SCHEMBL599641 0.77 ALDH1A1 (0.52) ACP3ALDH1A1CYP2C19CYP1A2CYP2C9
SCHEMBL6366676 0.72 CYP2C9 (0.49) ACP3ALDH1A1CYP2C19CYP1A2CYP2C9
SCHEMBL1863359 0.72 CYP2C9 (0.49) ACP3ALDH1A1CYP2C19CYP1A2CYP2C9
SCHEMBL6366679 0.72 CYP2C9 (0.49) ACP3ALDH1A1CYP2C19CYP1A2CYP2C9
SCHEMBL14033098 0.72 ACP3 (0.49) ACP3ALDH1A1KMT2ACYP2C19CYP1A2
SCHEMBL4661478 0.72 ACP3 (0.41) ACP3ALDH1A1KMT2AMGAMGAA
SCHEMBL11542549 0.72 CYP2C9 (0.46) ACP3ALDH1A1GAACYP2C19CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115008-B2 Method for producing optically active ester and method for producing optically active carboxylic acid TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-02-14 US disclosed