Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 10/20 | 0.48 |
| ▸ | CDK8 | P49336 | 10/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5999389 | 0.99 | KDR (0.51) | KDRSRCABL1YES1PDGFRB | |
| SCHEMBL5998458 | 0.89 | MAPK14 (0.56) | KDRSRCABL1PDGFRBLCK | |
| SCHEMBL5995241 | 0.84 | LMNA (0.56) | SRCABL1 | |
| SCHEMBL5996063 | 0.79 | PDGFRB (0.56) | KDRSRCABL1PDGFRBLCK | |
| SCHEMBL5996199 | 0.77 | SRC (0.54) | SRCPTK2CCNCCDK8LCK | |
| SCHEMBL5996051 | 0.77 | ABL1 (0.55) | KDRSRCABL1LCKMAPK14 | |
| SCHEMBL5996066 | 0.76 | LCK (0.45) | KDRSRCABL1LCKMAPK14 | |
| SCHEMBL5997282 | 0.76 | SRC (0.59) | KDRSRCLCKMAPK14 | |
| SCHEMBL5995904 | 0.76 | MAPT (0.47) | KDRSRCABL1PDGFRBLCK | |
| SCHEMBL2493237 | 0.75 | MAPK14 (0.58) | KDRSRCABL1PDGFRBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247250-A1 | Pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247250-A1 | Pyrimidine inhibitors of kinases | DTYMK, SRC, DCK | KDR 348/4885SRC 2/4885ABL1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.