SCHEMBL5998601

SCHEMBL5998601

CN1C(=O)Cc2cc(N3C[C@H](C(N)=O)OC3=O)ccc21

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.51
SMYD3 Q9H7B4 1/20 0.42
GAA P10253 2/20 0.41
F10 P00742 2/20 0.40
ALDH1A1 P00352 1/20 0.38
MAOB P27338 2/20 0.37
TRIM24 O15164 2/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
MAPT P10636 1/20 0.36
APOBEC3A P31941 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
LMNA P02545 1/20 0.35
PTGS1 P23219 1/20 0.35
CALML3 P27482 1/20 0.35
SDHA P31040 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6686796 0.89 MAOA (0.47) MAOAF10MAOBTRIM24
SCHEMBL3029206 0.89 MAOA (0.47) MAOAF10MAOBTRIM24
SCHEMBL5998091 0.87 F10 (0.41) MAOASMYD3GAAF10ALDH1A1
SCHEMBL5999489 0.87 F10 (0.41) MAOASMYD3GAAF10ALDH1A1
SCHEMBL5507911 0.85 MAOA (0.47) MAOAF10MAOBLMNAPTGS1
SCHEMBL5507922 0.85 MAOA (0.47) MAOAF10MAOBLMNAPTGS1
SCHEMBL5504072 0.85 MAOA (0.48) MAOAF10MAOBLMNAPTGS1
SCHEMBL5501276 0.85 MAOA (0.48) MAOAF10MAOBLMNAPTGS1
SCHEMBL20989998 0.85 MAOA (0.48) MAOAF10MAOBLMNAPTGS1
SCHEMBL5501286 0.85 MAOA (0.48) MAOAF10MAOBLMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060030609-A1 Oxazolidinones containing oxindoles as antibacterial agents LUEHR GARY W 2006-02-09 US claimed
US-20060030609-A1 Oxazolidinones containing oxindoles as antibacterial agents LUEHR GARY W 2006-02-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060030609-A1 Oxazolidinones containing oxindoles as antibacterial agents OXA1L, OXSR1, OXER1 MAOA 766/4885SMYD3 3313/4885GAA 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.