⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896464 | 0.78 | GPR4 (0.38) | — | |
| SCHEMBL1625991 | 0.78 | GPR4 (0.38) | — | |
| SCHEMBL27582741 | 0.77 | EDNRB (0.41) | — | |
| SCHEMBL1628192 | 0.76 | P2RX3 (0.40) | — | |
| SCHEMBL13578515 | 0.75 | — | — | |
| SCHEMBL1627271 | 0.75 | — | — | |
| SCHEMBL1626694 | 0.74 | TAAR1 (0.42) | — | |
| SCHEMBL27600129 | 0.74 | EDNRB (0.40) | — | |
| SCHEMBL27597652 | 0.73 | AGTR1 (0.39) | — | |
| SCHEMBL5774929 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148234-B2 | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases | PFIZER INC. (US) | 2006-12-12 | — | — | US | disclosed |
| US-20030236260-A1 | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases | SHIMOJO MASATO | 2003-12-25 | — | — | US | disclosed |