Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL5999891 | 0.88 | CYP19A1 (0.50) | CYP19A1TRPM8KCNA5SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL5999691 | 0.83 | PDE1B (0.42) | CYP19A1SLC6A2SLC6A4SLC6A3CYP11B1 | |
| Ammonia Solution, Strong SCHEMBL6000408 | 0.82 | SLC6A4 (0.49) | CYP19A1SLC6A2SLC6A4SLC6A3CYP11B1 | |
| SCHEMBL10446411 | 0.82 | CFTR (0.58) | CYP19A1KCNA5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2601111 | 0.82 | PNMT (0.47) | SLC6A2SLC6A4SLC6A3OPRM1OPRD1 | |
| Ammonia Solution, Strong SCHEMBL5998612 | 0.80 | TBXAS1 (0.43) | SLC6A2SLC6A4SLC6A3CYP11B1TBXAS1 | |
| Ammonia Solution, Strong SCHEMBL5999985 | 0.80 | KCNA5 (0.46) | CYP19A1KCNA5SLC6A2SLC6A4SLC6A3 | |
| Ammonia Solution, Strong SCHEMBL5999726 | 0.80 | KCNA5 (0.52) | CYP19A1TRPM8KCNA5SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL5999497 | 0.78 | CFTR (0.61) | KCNA5SLC6A2SLC6A4SLC6A3CYP11B1 | |
| SCHEMBL23565933 | 0.78 | TBXAS1 (0.43) | SLC6A2SLC6A4SLC6A3CYP11B1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | K AND K BIOSCIENCE, INC. (US) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | SIGMAR1, GRM1, GRIN2C | CYP19A1 4624/4885TRPM8 608/4885KCNA5 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.