SCHEMBL600004

SCHEMBL600004

CC(C(=O)O)(c1ccc(Cl)cc1)C(c1cccc2ccccc12)c1cccc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.43
PTGES2 Q9H7Z7 1/20 0.41
IDH1 O75874 1/20 0.41
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP2C19 P33261 2/20 0.39
CYP1A2 P05177 1/20 0.39
PTGES O14684 2/20 0.39
ALOX5 P09917 2/20 0.39
PPARG P37231 2/20 0.39
KMT2A Q03164 2/20 0.38
HPGD P15428 2/20 0.38
MEN1 O00255 1/20 0.38
ABCC9 O60706 1/20 0.38
ABCC8 Q09428 1/20 0.38
KCNJ11 Q14654 1/20 0.38
KCNJ8 Q15842 1/20 0.38
CYP2C9 P11712 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL600005 1.00 ACP3 (0.43) ACP3PTGES2IDH1ALDH1A1KDM4E
SCHEMBL599733 0.90 ALDH1A1 (0.45) ACP3ALDH1A1KDM4EHSD17B10CYP2C19
SCHEMBL598818 0.89 SCN2A (0.43) ALDH1A1KDM4EHSD17B10CYP2C19CYP1A2
SCHEMBL598817 0.89 SCN2A (0.43) ALDH1A1KDM4EHSD17B10CYP2C19CYP1A2
SCHEMBL17681454 0.88 ALOX5 (0.40) ACP3IDH1ALDH1A1KDM4EHSD17B10
SCHEMBL17681453 0.88 ALOX5 (0.40) ACP3IDH1ALDH1A1KDM4EHSD17B10
SCHEMBL606228 0.85 NPC1 (0.50) ALDH1A1KDM4EHSD17B10CYP2C19PPARG
SCHEMBL606229 0.85 NPC1 (0.50) ALDH1A1KDM4EHSD17B10CYP2C19PPARG
SCHEMBL17681404 0.85 CMA1 (0.45) ACP3ALDH1A1KDM4EHSD17B10CYP2C19
SCHEMBL17681405 0.85 CMA1 (0.45) ACP3ALDH1A1KDM4EHSD17B10CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9315442-B2 Method for manufacturing optically active carboxylic acid ester TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2016-04-19 US disclosed
US-8115008-B2 Method for producing optically active ester and method for producing optically active carboxylic acid TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) 2012-02-14 US disclosed