Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16813067 | 0.85 | GABRP (0.45) | HMGCRCHRM1TBXA2RADRA1ACYP2D6 | |
| SCHEMBL17570927 | 0.84 | ALDH1A1 (0.34) | MAPK1ALDH1A1TDP1CA1CA12 | |
| SCHEMBL23844664 | 0.84 | ALDH1A1 (0.34) | MAPK1ALDH1A1TDP1CA1CA12 | |
| SCHEMBL12700619 | 0.82 | HTT (0.36) | MAPK1ALDH1A1TDP1CA1CA12 | |
| SCHEMBL22104689 | 0.82 | ALDH1A1 (0.33) | MAPK1ALDH1A1TDP1CA1CA12 | |
| SCHEMBL25858401 | 0.82 | ALDH1A1 (0.33) | MAPK1ALDH1A1TDP1CA1CA12 | |
| SCHEMBL28772845 | 0.81 | HMGCR (0.35) | HMGCRCHRM1TBXA2RADRA1ACYP2D6 | |
| SCHEMBL13257754 | 0.81 | THRB (0.38) | MAPK1THRATHRBALDH1A1CA1 | |
| SCHEMBL12515883 | 0.80 | HMGCR (0.32) | HMGCRCHRM1TBXA2RADRA1ACYP2D6 | |
| SCHEMBL15934038 | 0.79 | CYP2D6 (0.34) | CYP2D6MAPK1ALDH1A1TDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017172914-A1 | METHODS AND COMPOSITIONS FOR MODULATING FRATAXIN EXPRESSION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-10-05 | — | — | WO | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |