Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28322173 | 0.84 | HTR3E (0.52) | GRM4HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2218837 | 0.82 | CHKA (0.49) | KDM4CCHKACHRM5MAPTMEN1 | |
| SCHEMBL13367477 | 0.79 | KDM4C (0.46) | KDM4CCHKACHRM5EGFRCSF1R | |
| SCHEMBL2222390 | 0.78 | CHKA (0.52) | KDM4CCHKACHRM5MAPTMEN1 | |
| SCHEMBL5998795 | 0.78 | GRM5 (0.45) | GRM5TAAR1CHKACHRM5EGFR | |
| SCHEMBL6000218 | 0.78 | ABCG2 (0.46) | KDM4CTAAR1CHKACHRM5KMT2A | |
| SCHEMBL2223507 | 0.78 | CHKA (0.56) | CHKACHRM5EGFRMAPTMEN1 | |
| SCHEMBL3409151 | 0.77 | CHRM5 (0.68) | CHKACHRM5MAPTMEN1KMT2A | |
| SCHEMBL6000381 | 0.76 | CHRM5 (0.45) | TAAR1CHKACHRM5MAPTMEN1 | |
| SCHEMBL17602063 | 0.75 | RELA (0.50) | KDM4CHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855308-A | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents | WARNER-LAMBERT COMPANY (US) | 1989-08-08 | — | — | US | claimed |
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | K AND K BIOSCIENCE, INC. (US) | 2006-03-16 | — | — | US | disclosed |
| US-4855308-A | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents | WARNER-LAMBERT COMPANY (US) | 1989-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058357-A1 | Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke | SIGMAR1, GRM1, GRIN2C | GRM4 31/4885KDM4C 2307/4885HTR3E 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.