Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.75 |
| ▸ | RAB9A | P51151 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 5/20 | 0.58 |
| ▸ | CLK1 | P49759 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.56 |
| ▸ | STK17B | O94768 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28327740 | 0.87 | NPC1 (0.78) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL3263663 | 0.86 | NPC1 (1.00) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL6239973 | 0.84 | PIM1 (0.60) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL28327743 | 0.82 | RAB9A (0.58) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL10412127 | 0.80 | FLT3 (0.53) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL3379125 | 0.80 | CLK1 (0.82) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL14994660 | 0.80 | FLT3 (0.75) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL657637 | 0.79 | NPC1 (0.70) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL30629241 | 0.79 | NPC1 (0.70) | NPC1RAB9ATSHRMAPK1MEN1 | |
| SCHEMBL1602739 | 0.79 | RAB9A (0.69) | NPC1RAB9ATSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407784-A | 2- sweet-smelling formacyl benzofuran derivatives or 2- sweet-smelling formacyl aphthofurans derivative and its synthetic method | UNIV SHANGHAI | 2019-11-05 | — | — | CN | disclosed |
| US-20060142271-A1 | Novel lapacho compounds and methods of use thereof | MUNSTER, UNIVERSITY OF (DE) | 2006-06-29 | — | — | US | disclosed |
| EP-1551392-A2 | NOVEL LAPACHO COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026253-A2 | NOVEL LAPACHO COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142271-A1 | Novel lapacho compounds and methods of use thereof | XIAP, PIN1, NQO1 | NPC1 1248/4885RAB9A 3906/4885TSHR 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.