Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002358 | 0.82 | TSHR (0.44) | TSHRALDH1A1HPGDCNR2PPARG | |
| SCHEMBL7094632 | 0.79 | TSHR (0.52) | TSHRALDH1A1HPGDCNR2GAA | |
| SCHEMBL4837680 | 0.77 | TSHR (0.53) | TSHRALDH1A1HPGDCNR2GAA | |
| SCHEMBL12255638 | 0.74 | TSHR (0.56) | TSHRALDH1A1HPGDCNR2GAA | |
| SCHEMBL13443169 | 0.73 | TSHR (0.54) | TSHRALDH1A1PPARGPOLBLMNA | |
| SCHEMBL3594770 | 0.71 | CYP4A11 (0.43) | TSHRALDH1A1HPGDGAALMNA | |
| SCHEMBL1558841 | 0.71 | ALDH1A1 (0.51) | TSHRALDH1A1HPGDGAAPOLB | |
| SCHEMBL28346434 | 0.70 | ALDH1A1 (0.46) | TSHRALDH1A1HPGDPPARGGAA | |
| SCHEMBL9442266 | 0.69 | TSHR (0.48) | TSHRALDH1A1PPARGPOLBLMNA | |
| SCHEMBL12851876 | 0.69 | ALDH1A1 (0.47) | TSHRALDH1A1HPGDGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655280-A1 | Dicarboxylic acid derivates with pharmaceutical properties | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| US-6864287-B1 | Derivatives of dicarboxylic acid having pharmaceutical properties | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-08 | — | — | US | disclosed |
| EP-1216222-A2 | NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES | Bayer Aktiengesellschaft (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019776-A2 | NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |