Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPRB | P23467 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507599 | 0.84 | PTPN1 (0.57) | PTPRCPTPN2PTPN1PTPRBPTPN6 | |
| SCHEMBL2539350 | 0.82 | L3MBTL1 (0.53) | PTPRCPTPN2PTPN1PTPRBPTPN6 | |
| SCHEMBL2294379 | 0.82 | RXRA (0.45) | PTPRCPTPN2PTPN1PTPRBPTPN6 | |
| SCHEMBL6044383 | 0.82 | MRGPRX4 (0.49) | RAB9AL3MBTL1RXRARXRBRXRG | |
| SCHEMBL768907 | 0.82 | MRGPRX4 (0.52) | RAB9AL3MBTL1RXRARXRBRXRG | |
| SCHEMBL692555 | 0.81 | HTR1A (0.67) | L3MBTL1HTR1ADRD2ALDH1A1ABCB1 | |
| SCHEMBL2290382 | 0.81 | PTPN1 (0.54) | PTPRCPTPN2PTPN1PTPRBPTPN6 | |
| SCHEMBL13009602 | 0.79 | HTR1A (0.74) | L3MBTL1HTR1ADRD2ALDH1A1ABCB1 | |
| SCHEMBL5641766 | 0.79 | MAPT (0.61) | RAB9AL3MBTL1HTR1ADRD2ALDH1A1 | |
| SCHEMBL12301141 | 0.79 | RXRA (0.58) | PTPRCPTPN2PTPN1PTPRBPTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655280-A1 | Dicarboxylic acid derivates with pharmaceutical properties | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| US-6864287-B1 | Derivatives of dicarboxylic acid having pharmaceutical properties | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-08 | — | — | US | disclosed |
| EP-1216222-A2 | NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES | Bayer Aktiengesellschaft (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019776-A2 | NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |