Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 4/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003292 | 0.88 | DYRK1B (0.45) | ALDH1A1HSD17B10ESR1DYRK1ACLK4 | |
| SCHEMBL8039455 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HSD17B10ESR1RIPK2KDR | |
| SCHEMBL8039453 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HSD17B10ESR1RIPK2KDR | |
| SCHEMBL4640548 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HSD17B10RIPK2KDREGFR | |
| SCHEMBL31609687 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HSD17B10RIPK2KDREGFR | |
| SCHEMBL7218395 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HSD17B10ESR1DYRK1ACLK4 | |
| SCHEMBL27362369 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HSD17B10ESR1DYRK1ACLK4 | |
| SCHEMBL1419323 | 0.72 | CYP2A6 (0.47) | ALDH1A1HSD17B10ESR1DYRK1ACLK4 | |
| SCHEMBL18911978 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HSD17B10ESR1DYRK1ACLK4 | |
| SCHEMBL6002187 | 0.71 | ALDH1A1 (0.46) | ALDH1A1HSD17B10NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |