Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 15/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 14/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 14/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 11/20 | 0.44 |
| ▸ | CLK2 | P49760 | 11/20 | 0.44 |
| ▸ | CLK3 | P49761 | 11/20 | 0.44 |
| ▸ | DYRK4 | Q9NR20 | 11/20 | 0.44 |
| ▸ | GSK3B | P49841 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002184 | 0.88 | ALDH1A1 (0.44) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL23480179 | 0.75 | DYRK1A (0.51) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL8517411 | 0.74 | IKBKB (0.55) | DYRK1AALDH1A1HSD17B10KDM4ENPC1 | |
| SCHEMBL6003293 | 0.72 | SLC6A4 (0.47) | ALDH1A1HSD17B10KDM4ENPC1RAB9A | |
| SCHEMBL28015693 | 0.72 | DYRK1A (0.49) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL7218352 | 0.72 | DYRK1A (0.49) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL1418925 | 0.72 | DYRK1A (0.52) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL19140129 | 0.72 | DYRK1A (0.52) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL27980410 | 0.72 | DYRK1A (0.49) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 | |
| SCHEMBL12903100 | 0.69 | DYRK1A (0.47) | DYRK1BDYRK1ADYRK2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |