Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001777 | 0.86 | SMN1; SMN2 (0.42) | MAPK1SMN1; SMN2PTPN1MMP2MMP13 | |
| SCHEMBL6001666 | 0.81 | KDM4E (0.52) | MAPK1SMN1; SMN2PTPN1MMP2MMP13 | |
| SCHEMBL6001795 | 0.75 | TP53 (0.59) | SMN1; SMN2 | |
| SCHEMBL6001740 | 0.74 | MMP13 (0.75) | MAPK1SMN1; SMN2MMP2MMP13MAPT | |
| SCHEMBL6001978 | 0.73 | NHERF1 (0.66) | MAPK1SMN1; SMN2 | |
| SCHEMBL3414863 | 0.72 | KDM4E (0.58) | MAPT | |
| SCHEMBL3412727 | 0.72 | F7 (0.58) | SMN1; SMN2MAPT | |
| SCHEMBL3268308 | 0.72 | KDM4E (0.56) | MAPT | |
| SCHEMBL6001817 | 0.71 | MAPK1 (0.43) | MAPK1SMN1; SMN2PTPN1CA2PTPN11 | |
| SCHEMBL5155719 | 0.70 | SMAD3 (0.57) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |