Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17666941 | 0.84 | ALDH1A1 (0.53) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL17666943 | 0.84 | ALDH1A1 (0.53) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL6002137 | 0.83 | POLB (0.46) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL6002241 | 0.80 | POLB (0.47) | POLBGAAALDH1A1KMT2ALMNA | |
| SCHEMBL6000574 | 0.80 | POLB (0.47) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL6002531 | 0.80 | ALDH1A1 (0.44) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL6000579 | 0.77 | POLB (0.41) | POLBGAAALDH1A1CTSLHTT | |
| SCHEMBL6002142 | 0.76 | HTT (0.49) | POLBGAAALDH1A1CTSLKMT2A | |
| SCHEMBL6002128 | 0.75 | ALDH1A1 (0.45) | POLBALDH1A1MAOA | |
| SCHEMBL6002032 | 0.72 | MAOA (0.44) | POLBGAAALDH1A1CTSLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1734939-A1 | ANTI-PARASITIC COMPOUNDS AND METHODS OF THEIR USE | The Regents of The University of California (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005087211-A1 | ANTI-PARASITIC COMPOUNDS AND METHODS OF THEIR USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-09-22 | — | — | WO | disclosed |