Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 12/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 12/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726674 | 0.80 | MAOB (0.59) | HSD17B1HSD17B2CYP2C9 | |
| SCHEMBL8469680 | 0.79 | HSD17B1 (0.61) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2095173 | 0.77 | HSD17B1 (0.49) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL4601434 | 0.77 | RXRA (0.50) | HSD17B1HSD17B2CYP3A4CYP2C9MKNK1 | |
| SCHEMBL5687510 | 0.73 | HSD17B1 (0.58) | HSD17B1HSD17B2CYP3A4CYP2C9PELI1 | |
| SCHEMBL21002206 | 0.72 | APP (0.77) | HSD17B1HSD17B2CYP3A4CYP2C9PELI1 | |
| SCHEMBL7898375 | 0.71 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL12656410 | 0.71 | HSD17B1 (0.96) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL13963701 | 0.71 | PDE10A (0.48) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29848168 | 0.71 | HSD17B1 (0.96) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |