Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KCNN4 | O15554 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005378 | 0.85 | KCNN4 (0.57) | HTTKCNN4ALDH1A1KCNE1KCNQ1 | |
| SCHEMBL4001444 | 0.77 | ALDH1A1 (0.46) | HTTKCNN4ALDH1A1TSHRHTR7 | |
| SCHEMBL2171612 | 0.72 | KDM4E (0.44) | HTTKCNN4ALDH1A1HTR7SMN1; SMN2 | |
| SCHEMBL9748549 | 0.71 | ALDH1A1 (0.80) | HTTALDH1A1TSHRSMN1; SMN2HDAC1 | |
| SCHEMBL8356496 | 0.70 | KCNN4 (0.55) | HTTKCNN4KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL12833766 | 0.69 | KCNN4 (0.38) | HTTKCNN4ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3465944 | 0.69 | HTT (0.81) | HTTKCNN4ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3465945 | 0.69 | HTT (0.81) | HTTKCNN4ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1141842 | 0.68 | OGG1 (0.42) | HTTSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL9721792 | 0.68 | MAPT (0.46) | HTTKCNN4ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636221-A2 | NEW AZETIDINE COMPOUNDS | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110344-A2 | NEW AZETIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |