Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27776210 | 0.82 | MPL (0.49) | NOTUMKMOCYP11B1CYP11B2 | |
| SCHEMBL4046110 | 0.79 | RAB9A (0.37) | ALDH1A1RAB9AKDM4EMAPK1NPC1 | |
| SCHEMBL2093090 | 0.76 | IDO1 (0.49) | KMOALDH1A1MAOBRAB9AKDM4E | |
| SCHEMBL4049874 | 0.75 | NOTUM (0.34) | NOTUM | |
| SCHEMBL1202001 | 0.75 | NOTUM (0.42) | NOTUMALDH1A1CYP1A2GAARAB9A | |
| SCHEMBL27584582 | 0.75 | METAP2 (0.42) | ALDH1A1GAARAB9AKDM4EMAPK1 | |
| SCHEMBL17626110 | 0.74 | AHR (0.46) | NOTUMKMOALDH1A1GAARAB9A | |
| SCHEMBL1319204 | 0.73 | IDO1 (0.49) | NOTUMKMOALDH1A1GAAKDM4E | |
| SCHEMBL4044388 | 0.73 | TGFBR1 (0.33) | ALDH1A1RAB9AKDM4EIDO1TGFBR1 | |
| SCHEMBL4050038 | 0.73 | CYP1A2 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |