Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290216 | 1.00 | IMPDH2 (0.50) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL372048 | 0.89 | IMPDH2 (0.58) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL18525615 | 0.80 | ALDH1A1 (0.40) | IMPDH2ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL17137434 | 0.80 | NR4A2 (0.42) | IMPDH2ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL15275124 | 0.79 | IMPDH2 (0.50) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7290454 | 0.79 | IMPDH2 (0.50) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7284981 | 0.79 | IMPDH2 (0.50) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL17137555 | 0.79 | ALDH1A1 (0.41) | IMPDH2ALDH1A1HSD17B10 | |
| SCHEMBL14937519 | 0.78 | IMPDH2 (0.54) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL16431809 | 0.78 | IMPDH2 (0.51) | IMPDH2ALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |