Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PPM1A | P35813 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | DCK | P27707 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002285 | 0.85 | MAPT (0.34) | CYP1A2CYP2A6PPM1AMAPTNPC1 | |
| SCHEMBL2097025 | 0.81 | CYP1A2 (0.33) | CYP1A2CYP2A6MAPTALDH1A1GPR84 | |
| SCHEMBL6002741 | 0.78 | CYP2A6 (0.38) | CYP2A6MAPTNPC1RAB9ASREBF2 | |
| SCHEMBL2092452 | 0.75 | CYP1A2 (0.37) | CYP1A2CYP2A6MAPTALDH1A1KDM4E | |
| SCHEMBL2090417 | 0.72 | CYP2A6 (0.38) | CYP1A2CYP2A6MAPTTSHRALDH1A1 | |
| SCHEMBL27212341 | 0.69 | CYP1A2 (0.35) | CYP1A2CYP2A6MAPTNPC1ALDH1A1 | |
| SCHEMBL14048575 | 0.67 | MTNR1A (0.46) | CYP2A6MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL17232438 | 0.67 | KDM4E (0.39) | CYP1A2ALDH1A1KDM4ELMNA | |
| SCHEMBL2089506 | 0.67 | CYP1A2 (0.33) | CYP1A2CYP2A6MTNR1AMTNR1BGPR84 | |
| SCHEMBL7657320 | 0.65 | CYP1A2 (0.50) | CYP1A2CYP2A6NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |