Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | NAAA | Q02083 | 3/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 3/20 | 0.32 |
| ▸ | KDM5A | P29375 | 2/20 | 0.31 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002734 | 0.98 | SIGMAR1 (0.36) | SIGMAR1NAAAGPR84MAPTCYP1A2 | |
| SCHEMBL6003283 | 0.86 | MAPT (0.30) | MAPT | |
| SCHEMBL2093530 | 0.84 | SIGMAR1 (0.38) | SIGMAR1NAAAGPR84MAPTCYP1A2 | |
| SCHEMBL2095854 | 0.84 | SIGMAR1 (0.38) | SIGMAR1NAAAGPR84MAPTCYP1A2 | |
| SCHEMBL6001510 | 0.83 | IDO1 (0.37) | — | |
| SCHEMBL2090496 | 0.82 | SIGMAR1 (0.35) | SIGMAR1NAAAGPR84MAPTCYP1A2 | |
| SCHEMBL30833259 | 0.71 | SIGMAR1 (0.54) | SIGMAR1NAAAGPR84MAPTCYP1A2 | |
| SCHEMBL4941600 | 0.71 | GPR84 (0.34) | GPR84MAPTCYP1A2 | |
| SCHEMBL10358404 | 0.69 | SIGMAR1 (0.50) | SIGMAR1MAPTCYP1A2KDM5APHF8 | |
| SCHEMBL9122326 | 0.67 | SIGMAR1 (0.46) | SIGMAR1GPR84MAPTCYP1A2KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |