Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001761 | 0.87 | NISCH (0.43) | NISCHSCN5ACYP1A2NOTUMKDM4E | |
| SCHEMBL6002991 | 0.82 | XDH (0.40) | MAPT | |
| SCHEMBL4049982 | 0.75 | KIF11 (0.44) | NISCHNOTUMKDM4E | |
| SCHEMBL1317405 | 0.75 | NPC1 (0.46) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL27577279 | 0.72 | NPC1 (0.46) | NISCHNPC1RAB9A | |
| SCHEMBL16238185 | 0.72 | NOTUM (0.33) | NISCHSCN5ANOTUM | |
| SCHEMBL6002662 | 0.71 | MCL1 (0.41) | CYP1A2NOTUMMAPT | |
| SCHEMBL6002864 | 0.71 | NOTUM (0.34) | NISCHSCN5ANOTUM | |
| SCHEMBL17625952 | 0.71 | NQO1 (0.47) | KDM4ENPC1ALDH1A1GAAMAPT | |
| SCHEMBL6003511 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |