Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.36 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indoline SCHEMBL28874564 | 0.88 | PARP11 (0.40) | ADRA1ADDB1CRBNPARP1PDPK1 | |
| SCHEMBL441521 | 0.72 | NOS1 (0.39) | NOS1NOS3NOS2ADRA1ADDB1 | |
| SCHEMBL1012779 | 0.70 | NOS1 (0.40) | NOS1NOS3NOS2ADRA1AHTR1A | |
| SCHEMBL29357835 | 0.70 | NOS1 (0.40) | NOS1NOS3NOS2ADRA1AHTR1A | |
| SCHEMBL9745024 | 0.67 | HTR2B (0.39) | ADRA1ALMNAADRA2ACYP2D6ADRA1D | |
| SCHEMBL24598116 | 0.66 | HTR2A (0.41) | NOS1NOS3NOS2PARP1MEN1 | |
| SCHEMBL19565614 | 0.66 | ADRA1A (0.47) | NOS1NOS3NOS2ADRA1AMEN1 | |
| SCHEMBL4592058 | 0.66 | NOS1 (0.36) | NOS1NOS3NOS2ADRA1A | |
| SCHEMBL18556688 | 0.65 | NOS1 (0.38) | NOS1NOS3NOS2ADRA1AMEN1 | |
| SCHEMBL19183045 | 0.65 | CYP19A1 (0.41) | ADRA1ADDB1CRBNPARP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260188-A | Preparation method of tetrahydro-beta-carbolinone compound | 浙江理工大学 | 2022-11-01 | — | — | CN | claimed |
| WO-2006011750-A1 | TETRAHYDRO-BETA-CARBOLINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME | C & C RESEARCH LABORATORIES (KR) | 2006-02-02 | — | — | WO | claimed |
| CN-115260188-A | Preparation method of tetrahydro-beta-carbolinone compound | 浙江理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-115260188-A | Preparation method of tetrahydro-beta-carbolinone compound | 浙江理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-115260188-A | Preparation method of tetrahydro-beta-carbolinone compound | 浙江理工大学 | 2022-11-01 | — | — | CN | disclosed |
| US-20140194429-A1 | COMPOSITIONS FOR TREATMENT OF CANCER | NOVARX CORPORATION | 2014-07-10 | — | — | US | disclosed |
| WO-2006011750-A1 | TETRAHYDRO-BETA-CARBOLINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME | C & C RESEARCH LABORATORIES (KR) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006011750-A1 | TETRAHYDRO-BETA-CARBOLINONE DERIVATIVES AND PROCESS FOR PREPARING THE SAME | C & C RESEARCH LABORATORIES (KR) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194429-A1 | COMPOSITIONS FOR TREATMENT OF CANCER | TP53, MCL1, CD44 | NOS1 3474/4885NOS3 2609/4885NOS2 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.