SCHEMBL19183045

SCHEMBL19183045

O=C1c2ccccc2N=C2NCCC12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.41
MAPT P10636 5/20 0.35
TP53 P04637 2/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
MAPK10 P53779 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
LMNA P02545 4/20 0.33
ALDH1A1 P00352 4/20 0.33
KMT2A Q03164 3/20 0.33
TSHR P16473 2/20 0.33
MEN1 O00255 2/20 0.33
KDM4E B2RXH2 1/20 0.33
APAF1 O14727 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
HK1 P19367 1/20 0.33
GALK1 P51570 1/20 0.33
HKDC1 Q2TB90 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30377821 1.00 CYP19A1 (0.41) CYP19A1MAPTTP53NPC1RAB9A
SCHEMBL30495554 0.83 CYP19A1 (0.37) CYP19A1MAPTTP53NPC1RAB9A
SCHEMBL30495534 0.72 NR3C1 (0.30)
SCHEMBL10521141 0.70 CYP19A1 (0.57) CYP19A1ALDH1A1KMT2AMEN1KDM4E
SCHEMBL14650969 0.69 CYP19A1 (0.45) CYP19A1MAPTTP53NPC1RAB9A
SCHEMBL3880710 0.68 CYP19A1 (0.44) CYP19A1MAPTTP53NPC1RAB9A
SCHEMBL19565614 0.66 ADRA1A (0.47) ALDH1A1KMT2AMEN1HTR1AADRA2A
SCHEMBL6004098 0.65 NOS1 (0.36) MAPTLMNAALDH1A1KMT2AMEN1
SCHEMBL22430326 0.63 PARP1 (0.37) MAPTNPC1RAB9ASMN1; SMN2LMNA
SCHEMBL24109389 0.61 LMNA (0.41) CYP19A1MAPTSMN1; SMN2LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112584832-A Non-muscle myosin II inhibitors for substance use relapse 斯克里普斯研究学院 2021-03-30 CN disclosed
EP-3529249-A1 WATER-SOLUBLE MYOSIN 2 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL, NEUROPATHIC OR PSYCHIATRIC DISEASES Paris Sciences et Lettres - Quartier Latin (FR) 2019-08-28 EP disclosed
WO-2017129782-A1 WATER-SOLUBLE MYOSIN 2 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL, NEUROPATHIC OR PSYCHIATRIC DISEASES PARIS SCIENCES ET LETTRES - QUARTIER LATIN (FR) 2017-08-03 WO disclosed