Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002912 | 0.88 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1EGFRMAPT | |
| SCHEMBL6002915 | 0.87 | TGFBR1 (0.45) | TGFBR1KDM4ENPC1EGFRSMN1; SMN2 | |
| SCHEMBL6004756 | 0.86 | TGFBR1 (0.56) | TGFBR1KDM4ENPC1EGFRMAPT | |
| SCHEMBL6004264 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1EGFRMAPT | |
| SCHEMBL6004691 | 0.84 | TGFBR1 (0.52) | TGFBR1EGFRKDR | |
| SCHEMBL6004714 | 0.80 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1EGFRKDR | |
| SCHEMBL6004360 | 0.80 | MRGPRX1 (0.58) | TGFBR1KDM4ENPC1KDRSMN1; SMN2 | |
| SCHEMBL6002846 | 0.80 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1EGFRCYP1A2 | |
| SCHEMBL6004307 | 0.75 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL6002965 | 0.75 | TGFBR1 (0.49) | TGFBR1KDM4ENPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |