Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004691 | 0.87 | TGFBR1 (0.52) | TGFBR1ATMEGFRCSF1R | |
| SCHEMBL6002912 | 0.87 | TGFBR1 (0.48) | TGFBR1NPC1ALDH1A1GAAMAPT | |
| SCHEMBL6002915 | 0.86 | TGFBR1 (0.45) | TGFBR1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6004166 | 0.86 | TGFBR1 (0.45) | TGFBR1NPC1ALDH1A1MAPTNPSR1 | |
| SCHEMBL6004185 | 0.86 | TGFBR1 (0.59) | TGFBR1ATMNPC1RAB9ARUNX1 | |
| SCHEMBL6002928 | 0.85 | TGFBR1 (0.40) | TGFBR1MAPTEGFRRAF1BRAF | |
| SCHEMBL6004231 | 0.80 | TGFBR1 (0.59) | TGFBR1NPC1KDM4E | |
| SCHEMBL6004360 | 0.79 | MRGPRX1 (0.58) | TGFBR1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6004714 | 0.79 | TGFBR1 (0.46) | TGFBR1NPC1EGFRKDM4EFLT3 | |
| SCHEMBL6004743 | 0.74 | KDR (0.50) | EGFRRAF1BRAFCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |