Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002895 | 0.92 | TGFBR1 (0.48) | TGFBR1MAOAKDM4ENPC1 | |
| SCHEMBL6004231 | 0.87 | TGFBR1 (0.59) | TGFBR1METKDM4ENPC1 | |
| SCHEMBL6004931 | 0.86 | TGFBR1 (0.48) | TGFBR1METMAOATLR8KDM4E | |
| SCHEMBL3903240 | 0.85 | TGFBR1 (0.49) | TGFBR1MET | |
| SCHEMBL6004761 | 0.85 | TGFBR1 (0.49) | TGFBR1MET | |
| SCHEMBL6004802 | 0.85 | TGFBR1 (0.48) | TGFBR1METKDM4ENPC1 | |
| SCHEMBL6004261 | 0.84 | TGFBR1 (0.48) | TGFBR1TLR8KDM4ENPC1 | |
| SCHEMBL6005332 | 0.83 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004158 | 0.82 | RET (0.47) | TGFBR1METTLR8KDM4ENPC1 | |
| SCHEMBL6004307 | 0.82 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |