Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PTP4A3 | O75365 | 3/20 | 0.47 |
| ▸ | PTP4A2 | Q12974 | 2/20 | 0.47 |
| ▸ | PTP4A1 | Q93096 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17318014 | 0.73 | ERCC5 (0.49) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4902650 | 0.70 | MCL1 (0.46) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1523074 | 0.68 | ERCC5 (0.54) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11614312 | 0.67 | CYP1A1 (0.52) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4515919 | 0.67 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2MAPTPTP4A3 | |
| SCHEMBL1884360 | 0.66 | FEN1 (1.00) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9098195 | 0.66 | ERCC5 (0.48) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19211158 | 0.66 | NPC1 (0.58) | FEN1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1341449 | 0.65 | PRKDC (0.54) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2236236 | 0.65 | CYP1A1 (0.55) | ERCC5FEN1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |