Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004840 | 0.92 | TGFBR1 (0.50) | TGFBR1KDM4ENPC1CBFBGAK | |
| SCHEMBL3896210 | 0.87 | GAK (0.37) | TGFBR1GAKKDR | |
| SCHEMBL6004802 | 0.85 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004307 | 0.85 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1BRAF | |
| SCHEMBL6004261 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004842 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1MAPK14 | |
| SCHEMBL6002846 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1GAK | |
| SCHEMBL6004134 | 0.84 | KDM4E (0.52) | TGFBR1KDM4ENPC1CBFB | |
| SCHEMBL6004231 | 0.83 | TGFBR1 (0.59) | TGFBR1KDM4ENPC1KDR | |
| SCHEMBL6005332 | 0.83 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |