Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.39 |
| ▸ | GAK | O14976 | 3/20 | 0.39 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.39 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004561 | 0.92 | TGFBR1 (0.48) | TGFBR1CBFBKDM4ENPC1GAK | |
| SCHEMBL6004657 | 0.86 | TGFBR1 (0.57) | TGFBR1CBFBKDM4ENPC1 | |
| SCHEMBL6002965 | 0.86 | TGFBR1 (0.49) | TGFBR1CBFBKDM4ENPC1 | |
| SCHEMBL6005291 | 0.85 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004307 | 0.85 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1BRAF | |
| SCHEMBL6004725 | 0.84 | TGFBR1 (0.48) | TGFBR1CBFBKDM4ENPC1RIPK2 | |
| SCHEMBL6004226 | 0.84 | TGFBR1 (0.48) | TGFBR1CBFBKDM4ENPC1AAK1 | |
| SCHEMBL6004264 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1EGFRKMT2A | |
| SCHEMBL6004134 | 0.84 | KDM4E (0.52) | TGFBR1CBFBKDM4ENPC1 | |
| SCHEMBL6004154 | 0.83 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |