Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004704 | 0.87 | DHODH (0.46) | DHODHCSNK2A2CSNK2BL3MBTL1MEN1 | |
| SCHEMBL1326238 | 0.80 | PDE10A (0.61) | DHODHL3MBTL1MEN1KMT2APDE10A | |
| SCHEMBL6005315 | 0.75 | EGFR (0.51) | L3MBTL1EGFRPDGFRBPDGFRAKDM4E | |
| SCHEMBL1501735 | 0.75 | AKT1 (0.48) | DHODHMEN1KMT2APIP4K2ATNF | |
| SCHEMBL13357728 | 0.74 | KDM4E (0.52) | DHODHCSNK2A2CSNK2BL3MBTL1MEN1 | |
| SCHEMBL13818403 | 0.74 | KDM4E (0.49) | DHODHCSNK2A2CSNK2BL3MBTL1MEN1 | |
| SCHEMBL28149552 | 0.72 | DAO (0.42) | EGFRPDGFRBPDGFRAMAPK10KDM4E | |
| SCHEMBL6004354 | 0.72 | HPGD (0.58) | EGFRPDGFRBPDGFRAPDE10AMAPK10 | |
| SCHEMBL9151290 | 0.70 | PDGFRB (0.66) | EGFRPDGFRBPDGFRAMAPK10KDM4E | |
| SCHEMBL27656250 | 0.69 | CYP11B1 (0.57) | DHODHMEN1KMT2APDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |