Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | RAD51 | Q06609 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004704 | 0.89 | DHODH (0.46) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL10836416 | 0.79 | CYP11B1 (0.50) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL6004865 | 0.76 | L3MBTL1 (0.54) | EGFRPDGFRBPDGFRARAD51KDM4E | |
| SCHEMBL8191361 | 0.75 | CYP2A6 (0.54) | RAD51KDM4ECYP11B1CYP19A1CYP11B2 | |
| SCHEMBL6004697 | 0.75 | DHODH (0.45) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL3894652 | 0.75 | CYP11B1 (0.53) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL3900693 | 0.74 | CYP2A6 (0.51) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL10837807 | 0.74 | FGFR1 (0.49) | EGFRPDGFRBPDGFRAKDM4ENPC1 | |
| SCHEMBL7964504 | 0.71 | RAD51 (0.60) | RAD51KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL8055700 | 0.71 | ACHE (0.53) | EGFRPDGFRBPDGFRARAD51KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |