Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3897825 | 0.86 | SRC (0.50) | TGFBR1PDGFRBPDGFRA | |
| SCHEMBL3907471 | 0.82 | SRC (0.44) | TGFBR1CYP3A4CYP2D6KDRPDGFRB | |
| SCHEMBL6004204 | 0.82 | TGFBR1 (0.39) | TGFBR1BRAF | |
| SCHEMBL6004844 | 0.81 | TGFBR1 (0.44) | TGFBR1CYP2A6ALDH1A1MEN1KMT2A | |
| SCHEMBL6002905 | 0.81 | TGFBR1 (0.44) | TGFBR1CYP2A6RIPK2RETKDR | |
| SCHEMBL6004307 | 0.80 | TGFBR1 (0.52) | TGFBR1MAPTALDH1A1NPSR1BRAF | |
| SCHEMBL3901753 | 0.80 | PDPK1 (0.55) | TGFBR1KDR | |
| SCHEMBL3905940 | 0.80 | TGFBR1 (0.40) | TGFBR1BRAF | |
| SCHEMBL3903438 | 0.79 | SRC (0.46) | TGFBR1CYP3A4CYP2D6KDRPDGFRB | |
| SCHEMBL3894713 | 0.79 | SRC (0.43) | TGFBR1CYP3A4CYP2D6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |