Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | GRK2 | P25098 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31241113 | 0.91 | POLB (0.68) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL6004315 | 0.83 | MEN1 (0.63) | SMN1; SMN2L3MBTL1GRK2CTDSP1ALDH1A1 | |
| SCHEMBL1762219 | 0.82 | NPC1 (0.59) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL6005485 | 0.81 | ALDH1A1 (0.56) | SMN1; SMN2NPC1L3MBTL1ALDH1A1POLB | |
| SCHEMBL13536979 | 0.81 | KDM4E (0.55) | SMN1; SMN2NPC1TDP1CTDSP1POLB | |
| SCHEMBL23973932 | 0.81 | NPC1 (0.58) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL12069248 | 0.81 | NPC1 (0.58) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL7933341 | 0.81 | NPC1 (0.58) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL31642790 | 0.80 | THRB (0.66) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 | |
| SCHEMBL10629048 | 0.80 | MAPT (0.53) | SMN1; SMN2NPC1L3MBTL1TDP1GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060167087-A1 | Substituted aniline derivatives | H. LUNDBECK A/S (DK) | 2006-07-27 | — | — | US | disclosed |
| CN-1759099-A | Substituted aniline derivatives | LUNDBECK & CO AS H (DK) | 2006-04-12 | — | — | CN | disclosed |
| EP-1606247-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. Lundbeck A/S (DK) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080950-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167087-A1 | Substituted aniline derivatives | CYP3A43, UGT2B7, CYP3A7 | SMN1; SMN2 1408/4885NPC1 237/4885L3MBTL1 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.