Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065318 | 0.78 | TDP1 (0.74) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL3079522 | 0.78 | TDP1 (0.68) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL32660136 | 0.78 | TDP1 (0.74) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL19642850 | 0.75 | TDP1 (0.63) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL2082545 | 0.73 | TDP1 (0.66) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL5841697 | 0.73 | TDP1 (0.51) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL10962344 | 0.72 | POLB (0.49) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL4313381 | 0.72 | CYP11B1 (0.62) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL3862944 | 0.72 | TDP1 (0.70) | TDP1HTTCYP11B1CYP11B2TNF | |
| SCHEMBL30038122 | 0.72 | TDP1 (0.70) | TDP1HTTCYP11B1CYP11B2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102378761-A | Pyridine thio derivative, and pharmaceutical composition which contains same and has anti-helicobacter pylori action | ARIGEN PHARMACEUTICALS INC | 2012-03-14 | — | — | CN | disclosed |
| EP-2420500-A1 | PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION | aRigen Pharmaceuticals, Inc. (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-20120041030-A1 | PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION | LINK GENOMICS, INC. (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041030-A1 | PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION | TPMT, TST, PTPN11 | TDP1 2594/4885HTT 987/4885CYP11B1 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.