Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879818 | 0.77 | HTT (0.48) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL8013907 | 0.75 | TDP1 (0.52) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL273486 | 0.75 | TDP1 (0.52) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL600507 | 0.72 | TDP1 (0.54) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL10532236 | 0.72 | FBP1 (0.42) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL599672 | 0.72 | POLB (0.45) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL20683088 | 0.72 | TDP1 (0.48) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL6381049 | 0.72 | TDP1 (0.48) | POLBTDP1HTTTNFCYP11B1 | |
| SCHEMBL5337371 | 0.71 | RAB9A (0.50) | POLBEHMT2EHMT1APOBEC3GHTT | |
| SCHEMBL28067710 | 0.71 | CYP11B1 (0.46) | POLBTDP1HTTTNFCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167943-A2 | Benzimidazole derivatives, process for their preparation, and their use as pharmaceuticals | BEECHAM GROUP PLC (GB) | 1986-01-15 | — | — | EP | disclosed |