Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Cytidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | MTOR | P42345 | 2/20 | 0.80 |
| ▸ | THRB | P10828 | 1/20 | 0.80 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.80 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.80 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.80 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.76 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.76 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.76 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.76 |
| ▸ | P2RY2 | P41231 | 9/20 | 0.70 |
| ▸ | P2RY6 | Q15077 | 5/20 | 0.59 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytidine SCHEMBL17371752 | 1.00 | LMNA (0.80) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL1829999 | 0.92 | LMNA (0.74) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6037075 | 0.92 | LMNA (0.67) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6037074 | 0.92 | LMNA (0.67) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL23066241 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL172274 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL17993618 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL20546595 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine SCHEMBL329878 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytidine SCHEMBL8525830 | 0.90 | LMNA (1.00) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10761099-B2 | Compositions and methods for treatment of lung function | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2020-09-01 | — | — | US | claimed |
| CN-107142320-A | Gene marker for detecting liver cancer and application thereof | 上海易毕恩基因科技有限公司 | 2017-09-08 | — | — | CN | claimed |
| CN-103031285-B | Cordyceps Chinese Hirsutella uridine-cytidine kinase, coding gene and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-12-17 | — | — | CN | claimed |
| CN-103031285-A | Cordyceps Chinese Hirsutella uridine-cytidine kinase, coding gene and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2013-04-10 | — | — | CN | claimed |
| US-6475730-B1 | Detecting nucleic acids | THE VICTORIA UNIVERSITY OF MANCHESTER (GB) | 2002-11-05 | — | — | US | claimed |
| EP-1141393-A2 | DETECTING NUCLEIC ACIDS | THE VICTORIA UNIVERSITY OF MANCHESTER (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000040751-A2 | DETECTING NUCLEIC ACIDS | THE VICTORIA UNIVERSITY OF MANCHESTER (GB) | 2000-07-13 | — | — | WO | claimed |
| US-5422343-A | Administering inosine, guanosine, adenosine, uridine, cytidine and/or their monophosphates(or mixtures) for methicillin-resistant staphylococcus aureus infections | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-06-06 | — | — | US | claimed |
| CN-117835984-A | Treatment of RNA viral infection using cytidine deaminase inhibitors | 克利夫兰诊所基金会 | 2024-04-05 | — | — | CN | disclosed |
| CN-117016549-B | Application of nucleoside compound and composition thereof in promoting plant growth | 山东蓬勃生物科技有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-11860162-B2 | Marker sequences for diagnosing and stratifying SLE patients | ONCIMMUNE GERMANY GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| CN-117016549-A | Application of nucleoside compound and composition thereof in promoting plant growth | 山东蓬勃生物科技有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-117003805-A | Process for separating and purifying UMP feed liquid by sequential continuous ion exchange method | 南京工业大学 | 2023-11-07 | — | — | CN | disclosed |
| US-20230295637-A1 | METHODS FOR REDUCING RNA IMMUNOGENICITY AND RNA MOLECULES WITH DECREASED IMMUNOGENICITY | RIBOPRO B.V. (NL) | 2023-09-21 | — | — | US | disclosed |
| CN-101172993-A | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections | CENTRE NAT RECH SCIENT (KY) | 2008-05-07 | — | — | CN | disclosed |
| CN-101023185-A | Biomarkers for monitoring inhibition of impdh pathway | VERTEX PHARMA (US) | 2007-08-22 | — | — | CN | disclosed |
| US-20070082332-A1 | Molecular cardiotoxicology modeling | GENE LOGIC, INC. | 2007-04-12 | — | — | US | disclosed |
| CN-1692161-A | Treatment for asthma or allergies | CHILDRENS HOSP MEDICAL CT (US) | 2005-11-02 | — | — | CN | disclosed |
| WO-2005023979-A2 | ISOLATED S. MANSONI NUCLEIC ACID MOLECULES AND USES THEREOF | Fundação De Amparo À Pesquisa Do Estado de São Paulo (BR) | 2005-03-17 | — | — | WO | disclosed |
| WO-2004047855-A2 | PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS | DEVELOGEN AKTIENGESELLSCHAFT FUR ENTWICKLUNGSBIOLOGISCHE FORSCHUNG (DE) | 2004-06-10 | — | — | WO | disclosed |