Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6392226 | 0.92 | SCN2A (0.66) | SCN2AKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11307122 | 0.81 | CYP3A4 (0.56) | SCN2AKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11593418 | 0.81 | SCN2A (0.60) | SCN2AKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11808285 | 0.80 | ESR1 (0.72) | SCN2AKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL18470146 | 0.80 | MAPT (0.56) | SCN2AKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL6156837 | 0.76 | SCN2A (0.57) | SCN2AKMT2AMEN1ALDH1A1NR1H3 | |
| SCHEMBL6005484 | 0.75 | SCN2A (0.53) | SCN2AKMT2AMEN1ALDH1A1ESR1 | |
| SCHEMBL92071 | 0.75 | ALDH1A1 (0.95) | KMT2AMAPTMEN1ALDH1A1THRB | |
| SCHEMBL29168849 | 0.74 | KMT2A (0.76) | SCN2AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL30758650 | 0.74 | KMT2A (0.76) | SCN2AKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682555-A1 | MACROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047294-A1 | MACROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-05-26 | — | — | WO | disclosed |