Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | OXTR | P30559 | 7/20 | 0.49 |
| ▸ | CCKBR | P32239 | 8/20 | 0.49 |
| ▸ | CCKAR | P32238 | 7/20 | 0.49 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003690 | 0.85 | KCNH2 (0.59) | KCNH2OXTRCCKBRCALCRL | |
| SCHEMBL7098528 | 0.82 | KCNH2 (0.58) | KCNH2OXTRCALCRL | |
| SCHEMBL7212252 | 0.81 | CCKAR (0.64) | KCNH2CCKBRCCKAR | |
| SCHEMBL6006725 | 0.79 | CCKBR (0.68) | KCNH2OXTRCCKBRCCKAR | |
| SCHEMBL6005228 | 0.79 | CCKBR (0.68) | KCNH2OXTRCCKBRCCKAR | |
| SCHEMBL6006715 | 0.79 | CCKBR (0.68) | KCNH2OXTRCCKBRCCKAR | |
| SCHEMBL8462710 | 0.78 | KCNH2 (0.81) | KCNH2OXTRCALCRL | |
| SCHEMBL6005855 | 0.77 | PSEN1 (0.65) | KCNH2OXTRCALCRL | |
| SCHEMBL7097812 | 0.77 | CCKBR (0.61) | KCNH2OXTRCCKBRCCKAR | |
| SCHEMBL6005992 | 0.76 | CCKBR (0.62) | KCNH2OXTRCCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | KCNH2 1795/4885OXTR 773/4885CCKBR 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.