Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31240148 | 1.00 | PTGS2 (0.48) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL27654524 | 0.86 | HDAC1 (0.43) | LMNATSHRHDAC1HDAC6 | |
| SCHEMBL7962599 | 0.82 | PTGS2 (0.50) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL3636643 | 0.81 | LMNA (0.47) | LMNATSHRBLMHDAC1HDAC6 | |
| SCHEMBL10666788 | 0.80 | MT-CO2 (0.46) | PTGS2PTGS1LMNAHDAC1HDAC6 | |
| SCHEMBL31420077 | 0.79 | NAPRT (0.48) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL25810696 | 0.79 | PTGS2 (0.47) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL29009823 | 0.79 | PTGS2 (0.47) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL1747676 | 0.79 | NAPRT (0.48) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL10664684 | 0.79 | KMT2A (0.48) | AKR1C3AKR1C2PTGS1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040952-A1 | AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2012-02-16 | — | — | US | disclosed |
| EP-1070052-A1 | FUNGICIDE COMPOSITIONS COMPRISING A HYDROXIMIC OR HYDRAZONIC GROUP | AVENTIS CROPSCIENCE S.A. (FR) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051579-A1 | FUNGICIDE COMPOSITIONS COMPRISING A HYDROXIMIC OR HYDRAZONIC GROUP | AVENTIS CROPSCIENCE S.A. (FR) | 1999-10-14 | — | — | WO | disclosed |
| EP-0070185-B1 | PREPARATION OF LOWER ALKYL 2-FORMYL-3-(6-METHYL-3-PYRIDINYL)-PROPIONATES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040952-A1 | AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | HRH3, HRH2, HRH1 | PTGS2 2028/4885AKR1C3 840/4885AKR1C2 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.